HDAC inhibition protects degenerating cone photoreceptors in vivo

نویسندگان

  • Dragana Trifunović
  • Blanca Arango-Gonzalez
  • Antonella Comitato
  • Melanie Barth
  • Ayse Sahaboglu
  • Eva M. del Amo
  • Manoj Kulkarni
  • Stefanie M. Hauck
  • Marius Ueffing
  • Arto Urtti
  • Yvan Arsenijevic
  • Valeria Marigo
  • François Paquet-Durand
  • Ophtalmique Jules Gonin
چکیده

Affiliations Institute for Ophthalmic Research, University of Tuebingen, 72076 Tuebingen, Germany Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland Research Unit Protein Science, Helmholtz Center Munich, 85764 Neuherberg, Germany Centre for Drug Research, Division of Pharmaceutical Bioscience, University of Helsinki, 00014 Helsinki, Finland Unit of Gene Therapy & Stem Cell Biology, Hôpital Ophtalmique Jules Gonin, 1004 Lausanne, Switzerland These authors contributed equally to this work

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Histochemical study of retinal photoreceptors development during pre- and postnatal period and their association with retinal pigment epithelium

Objective(s):The aim of this study was to evaluate distribution and changes of glycoconjugates of retinal photoreceptors during both pre- and postnatal development. Materials and Methods: Tissue sections from days 15 to 20 of Wistar rat embryos and 1 to 12 postnatal days of rat newborns including developing eye were prepared for lectinhistochemistry technique. Horseradish peroxidase (HRP)-label...

متن کامل

RhoA and its role in synaptic structural plasticity of isolated salamander photoreceptors.

PURPOSE Adult salamander photoreceptors retract existing axons and extend new neuritic processes in vitro. In mammalian retina, similar forms of structural plasticity occur in injury and disease. The authors asked whether RhoA is present in photoreceptor axon terminals and whether activity in the RhoA-ROCK pathway contributes to the structural plasticity observed in rod and cone cells. METHOD...

متن کامل

In vivo imaging of human cone photoreceptor inner segments.

PURPOSE An often overlooked prerequisite to cone photoreceptor gene therapy development is residual photoreceptor structure that can be rescued. While advances in adaptive optics (AO) retinal imaging have recently enabled direct visualization of individual cone and rod photoreceptors in the living human retina, these techniques largely detect strongly directionally-backscattered (waveguided) li...

متن کامل

Inner Segment Remodeling and Mitochondrial Translocation in Cone Photoreceptors in Age-Related Macular Degeneration With Outer Retinal Tubulation.

PURPOSE To quantify impressions of mitochondrial translocation in degenerating cones and to determine the nature of accumulated material in the subretinal space with apparent inner segment (IS)-like features by examining cone IS ultrastructure. METHODS Human donor eyes with advanced age-related macular degeneration (AMD) were screened for outer retinal tubulation (ORT) in macula-wide, high-re...

متن کامل

Oncostatin M Protects Rod and Cone Photoreceptors and Promotes Regeneration of Cone Outer Segment in a Rat Model of Retinal Degeneration

Retinitis pigmentosa (RP) is a group of photoreceptor degenerative disorders that lead to loss of vision. Typically, rod photoreceptors degenerate first, resulting in loss of night and peripheral vision. Secondary cone degeneration eventually affects central vision, leading to total blindness. Previous studies have shown that photoreceptors could be protected from degeneration by exogenous neur...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016